Measuring Cannabinoid Receptors in Veterans

This study consists of one MRI scan; MRI stands for Magnetic Resonance Imaging. This is a technique that uses radio waves and a strong magnetic field to look at oxygen levels in the brain. The more active a certain part of the brain is, the more oxygen it will require to function. This scan helps us see, in real time which parts of the brain are the most activated.

MRI Scans do not use any needles or radiation. We do, however, use closed MRI scanners, which some people may feel claustrophobia inducing. Please take this into account when considering participating in this study.

This study consists of one PET scan; PET stands for Positron Emission Tomography. This is a technique that uses the radioisotope Carbon-11 to visualize chemical activity in the brain. A specialized camera is used to form an image of these brain regions. Carbon-11 has a half life of 20 minutes. Therefore, it will decompose into harmless atoms after 20 minutes.

The PET Scan itself will take two hours and you will be asked to lie still for the duration of this scan. While there is some minor radiation exposure, it is about 1/10th of the Food and Drug Administration's annual radiation exposure regulation for research purposes.

About the Study

This exploratory neurobiological study analyzes the presence of the Cannabinoid Type 1 (CB1) receptor in the brain of those who have been exposed to trauma.

The CB1 receptor may play a role in learning and memory processes. Importantly, CB1 receptors have been found in brain regions that control fear and stress responses

Our study is made up of three appointments: a screening appointment to determine your eligibility, an MRI scan, and a PET scan. You can receive up to $650.00 compensation.

Our goal is to better understand the neurobiological underpinnings of PTSD and those exposed to trauma. This research may be applied to help improve future treatments for PTSD.